Evaluation of Retinal Nerve Fiber Layer Thickness and Visual Evoked Potential in Patients with Bipolar Disorder

Awis Qarni Fadil, Wan Hazabbah Wan Hitam, Asrenee Ab Razak, Mohammed Faruque Reza

Abstract


Objective: To evaluate the retinal nerve fibre layer (RNFL) thickness and visual evoked potential in patients with bipolar disorder (BPD).

Methods: A comparative cross-sectional, hospital-based study. 61 BPD subjects and 60 controls were recruited. Candidates that fulfilled the criteria with normal ocular examinations underwent Optical Coherent Tomography (OCT) for evaluation of retinal nerve fibre layer (RNFL) and visual evoked potential (VEP) test of the right eye.

Results: There was a statistically significant reduction in average RNFL thickness (adjusted mean 97.22µm vs 102.94µm, P = 0.034), superior RNFL thickness (adjusted mean 121.63µm vs 133.89µm, P = 0.007), nasal RNFL thickness (adjusted mean 69.64µm vs 78.15µm, P = 0.005), and temporal RNFL thickness (adjusted mean 67.18µm vs 75.62µm, P = 0.027) in BPD group compared to the control group. There was a statistically significant delay in P100 peak latency with 60-min of arc (adjusted mean 113.62ms vs 103.44ms, P < 0.001) and in P100 peak latency with 15-min of arc (adjusted mean 120.20ms vs 116.03ms, P = 0.012). There was also a statistically significant decreased amplitude of P100 with 60-min of arc (adjusted mean 8.97μV vs 12.47μV, P = 0.022). However, there was no significant correlation between average RNFL thickness and all parameters of VEP readings among the BPD patients.

Conclusion: The mean of the average, superior, nasal and temporal RNFL thickness were significantly lower in the BPD group compared to control. The P100 peak latency with 60-min and 15-min of arc are significantly delayed in the BPD group compared to control. The amplitude of P100 with 60-minute also statistically decreased in the BPD group compared to control. There was no significant correlation between average RNFL thickness and VEP readings in BPD patients. 

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Keywords


RNFL; VEP; Bipolar Disorder

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